The acute and the long‐term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
Identifieur interne : 001406 ( Main/Exploration ); précédent : 001405; suivant : 001407The acute and the long‐term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
Auteurs : Mahmoud M. Iravani [Royaume-Uni] ; Clement C. M. Leung [Royaume-Uni] ; Mona Sadeghian [Royaume-Uni] ; Claire O. Haddon [Royaume-Uni] ; Sarah Rose [Royaume-Uni] ; Peter Jenner [Royaume-Uni]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2005-07.
English descriptors
- KwdEn :
Abstract
Sustained reactive microgliosis may contribute to the progressive degeneration of nigral dopaminergic neurons in Parkinson's disease (PD), in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) exposed human and in non‐human primates. However, the temporal relationship between glial cell activation and nigral cell death is relatively unexplored. Consequently, the effects of acute (24 h) and chronic (30 days) glial cell activation induced by unilateral supranigral lipopolysaccharide (LPS) administration were studied in rats. At 24 h, LPS administration caused a marked reduction in the number of tyrosine hydroxylase‐immunoreactive (TH‐ir) neurons in the substantia nigra (SN) but striatal TH‐ir was unaffected. By 30 days, the loss of TH‐positive neurons in the LPS‐treated nigra was no greater than at 24 h although a heterogeneous loss of striatal TH‐ir was present. The loss of nigrostriatal neurons was of functional significance, as at 30 days, LPS‐treated rats exhibited ipsiversive circling in response to (+)‐amphetamine administration. At 24 h, there was a moderate increase in glial fibrillary acidic protein (GFAP)‐ir astrocytes in the SN but a marked elevation of p47phox positive OX‐42‐ir microglia, and intense inducible nitric oxide synthase (iNOS)‐ir and 3‐nitrotyrosine (3‐NT)‐ir was present. However, by 30 days the morphology of OX‐42‐ir microglia returned to a resting state, the numbers were greatly reduced and no 3‐NT‐ir was present. At 30 days, GFAP‐ir astrocytes were markedly increased in number and iNOS‐ir was present in fibrillar astrocyte‐like cells. This study shows that acute glial activation leading to dopaminergic neuron degeneration is an acute short‐lasting response that does not itself perpetuate cell death or lead to prolonged microglial activation.
Url:
DOI: 10.1111/j.1460-9568.2005.04220.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The acute and the long‐term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation</title>
<author><name sortKey="Iravani, Mahmoud M" sort="Iravani, Mahmoud M" uniqKey="Iravani M" first="Mahmoud M." last="Iravani">Mahmoud M. Iravani</name>
</author>
<author><name sortKey="Leung, Clement C M" sort="Leung, Clement C M" uniqKey="Leung C" first="Clement C. M." last="Leung">Clement C. M. Leung</name>
</author>
<author><name sortKey="Sadeghian, Mona" sort="Sadeghian, Mona" uniqKey="Sadeghian M" first="Mona" last="Sadeghian">Mona Sadeghian</name>
</author>
<author><name sortKey="Haddon, Claire O" sort="Haddon, Claire O" uniqKey="Haddon C" first="Claire O." last="Haddon">Claire O. Haddon</name>
</author>
<author><name sortKey="Rose, Sarah" sort="Rose, Sarah" uniqKey="Rose S" first="Sarah" last="Rose">Sarah Rose</name>
</author>
<author><name sortKey="Jenner, Peter" sort="Jenner, Peter" uniqKey="Jenner P" first="Peter" last="Jenner">Peter Jenner</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D02BA882473882E373C32595A00703C327672F72</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1111/j.1460-9568.2005.04220.x</idno>
<idno type="url">https://api.istex.fr/document/D02BA882473882E373C32595A00703C327672F72/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002308</idno>
<idno type="wicri:Area/Main/Curation">001F91</idno>
<idno type="wicri:Area/Main/Exploration">001406</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The acute and the long‐term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation</title>
<author><name sortKey="Iravani, Mahmoud M" sort="Iravani, Mahmoud M" uniqKey="Iravani M" first="Mahmoud M." last="Iravani">Mahmoud M. Iravani</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King's College, London, SE1 1UL</wicri:regionArea>
<wicri:noRegion>SE1 1UL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leung, Clement C M" sort="Leung, Clement C M" uniqKey="Leung C" first="Clement C. M." last="Leung">Clement C. M. Leung</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King's College, London, SE1 1UL</wicri:regionArea>
<wicri:noRegion>SE1 1UL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sadeghian, Mona" sort="Sadeghian, Mona" uniqKey="Sadeghian M" first="Mona" last="Sadeghian">Mona Sadeghian</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King's College, London, SE1 1UL</wicri:regionArea>
<wicri:noRegion>SE1 1UL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haddon, Claire O" sort="Haddon, Claire O" uniqKey="Haddon C" first="Claire O." last="Haddon">Claire O. Haddon</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King's College, London, SE1 1UL</wicri:regionArea>
<wicri:noRegion>SE1 1UL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rose, Sarah" sort="Rose, Sarah" uniqKey="Rose S" first="Sarah" last="Rose">Sarah Rose</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King's College, London, SE1 1UL</wicri:regionArea>
<wicri:noRegion>SE1 1UL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jenner, Peter" sort="Jenner, Peter" uniqKey="Jenner P" first="Peter" last="Jenner">Peter Jenner</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King's College, London, SE1 1UL</wicri:regionArea>
<wicri:noRegion>SE1 1UL</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">European Journal of Neuroscience</title>
<idno type="ISSN">0953-816X</idno>
<idno type="eISSN">1460-9568</idno>
<imprint><publisher>Blackwell Science Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="2005-07">2005-07</date>
<biblScope unit="volume">22</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="317">317</biblScope>
<biblScope unit="page" to="330">330</biblScope>
</imprint>
<idno type="ISSN">0953-816X</idno>
</series>
<idno type="istex">D02BA882473882E373C32595A00703C327672F72</idno>
<idno type="DOI">10.1111/j.1460-9568.2005.04220.x</idno>
<idno type="ArticleID">EJN4220</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0953-816X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>inducible nitric oxide synthase (iNOS)</term>
<term>inflammation</term>
<term>reactive gliosis</term>
<term>striatum</term>
<term>substantia nigra</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Sustained reactive microgliosis may contribute to the progressive degeneration of nigral dopaminergic neurons in Parkinson's disease (PD), in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) exposed human and in non‐human primates. However, the temporal relationship between glial cell activation and nigral cell death is relatively unexplored. Consequently, the effects of acute (24 h) and chronic (30 days) glial cell activation induced by unilateral supranigral lipopolysaccharide (LPS) administration were studied in rats. At 24 h, LPS administration caused a marked reduction in the number of tyrosine hydroxylase‐immunoreactive (TH‐ir) neurons in the substantia nigra (SN) but striatal TH‐ir was unaffected. By 30 days, the loss of TH‐positive neurons in the LPS‐treated nigra was no greater than at 24 h although a heterogeneous loss of striatal TH‐ir was present. The loss of nigrostriatal neurons was of functional significance, as at 30 days, LPS‐treated rats exhibited ipsiversive circling in response to (+)‐amphetamine administration. At 24 h, there was a moderate increase in glial fibrillary acidic protein (GFAP)‐ir astrocytes in the SN but a marked elevation of p47phox positive OX‐42‐ir microglia, and intense inducible nitric oxide synthase (iNOS)‐ir and 3‐nitrotyrosine (3‐NT)‐ir was present. However, by 30 days the morphology of OX‐42‐ir microglia returned to a resting state, the numbers were greatly reduced and no 3‐NT‐ir was present. At 30 days, GFAP‐ir astrocytes were markedly increased in number and iNOS‐ir was present in fibrillar astrocyte‐like cells. This study shows that acute glial activation leading to dopaminergic neuron degeneration is an acute short‐lasting response that does not itself perpetuate cell death or lead to prolonged microglial activation.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Iravani, Mahmoud M" sort="Iravani, Mahmoud M" uniqKey="Iravani M" first="Mahmoud M." last="Iravani">Mahmoud M. Iravani</name>
</noRegion>
<name sortKey="Haddon, Claire O" sort="Haddon, Claire O" uniqKey="Haddon C" first="Claire O." last="Haddon">Claire O. Haddon</name>
<name sortKey="Jenner, Peter" sort="Jenner, Peter" uniqKey="Jenner P" first="Peter" last="Jenner">Peter Jenner</name>
<name sortKey="Leung, Clement C M" sort="Leung, Clement C M" uniqKey="Leung C" first="Clement C. M." last="Leung">Clement C. M. Leung</name>
<name sortKey="Rose, Sarah" sort="Rose, Sarah" uniqKey="Rose S" first="Sarah" last="Rose">Sarah Rose</name>
<name sortKey="Sadeghian, Mona" sort="Sadeghian, Mona" uniqKey="Sadeghian M" first="Mona" last="Sadeghian">Mona Sadeghian</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001406 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001406 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:D02BA882473882E373C32595A00703C327672F72 |texte= The acute and the long‐term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation }}
This area was generated with Dilib version V0.6.23. |